What is a common side effect of using varenicline?

Varenicline is a medication commonly used to support smoking cessation by acting on nicotine receptors in the brain, partially stimulating them while simultaneously blocking nicotine from attaching to them. One of the most frequently reported side effects of varenicline is nausea. This gastrointestinal discomfort can occur in many users, particularly when they start the medication or increase the dosage. It is important to note that nausea is often transient and can decrease as the body adjusts to the drug.

The prevalence of this side effect is significant enough that healthcare providers typically advise taking the medication with food to mitigate stomach upset. Furthermore, patients are often counseled about this potential adverse effect when initiating treatment to prepare them for the experience and to encourage them to continue with the medication, as the benefits in achieving smoking cessation can outweigh the temporary discomfort of nausea.