What is a potential adverse effect of long-term systemic corticosteroid use?

Long-term systemic corticosteroid use is associated with hyperglycemia due to their impact on glucose metabolism. Corticosteroids can increase insulin resistance and elevate blood glucose levels by promoting gluconeogenesis, the process by which the liver produces glucose from non-carbohydrate sources. This is particularly significant for patients with underlying conditions, such as diabetes, where maintaining blood sugar levels is critical. The elevated blood sugar levels can lead to difficulties in effectively managing diabetes or even the development of steroid-induced diabetes in individuals without prior glucose regulation issues.

The other potential options do not align with the common side effects of corticosteroid use. Rapid weight loss is typically not associated with corticosteroids, as they often lead to weight gain. Increased energy levels are also not a common outcome; rather, corticosteroids can cause mood swings and changes in energy levels that may not be perceived as an increase in stamina. Decreased blood pressure is unlikely, as corticosteroids can cause sodium retention and fluid retention, which may contribute to increased blood pressure rather than a decrease. Thus, the relationship between corticosteroid use and hyperglycemia is well-documented, making it the correct response.