What major adverse effect warning is associated with montelukast?

Montelukast, a leukotriene receptor antagonist commonly used for the treatment of asthma and allergic rhinitis, has been associated with neuropsychiatric adverse effects, making this a significant concern for both patients and healthcare providers. These neuropsychiatric effects may include mood changes, depression, agitation, anxiety, and even suicidal thoughts or behavior in some individuals. Monitoring for these symptoms is essential, especially in populations with a history of mental health issues.

Understanding the potential for neuropsychiatric effects is critical for safely prescribing montelukast. This awareness can also guide discussions with patients about the benefits and risks of the medication, ensuring they are informed and can report any concerning symptoms. While other choices may present their own risks (such as gastrointestinal disturbances or skin reactions), the notable heightened warning for neuropsychiatric effects sets montelukast apart and emphasizes the necessity for caution when initiating treatment, particularly in at-risk populations.