Which medication is a commonly prescribed first-line option for smoking cessation?

Bupropion is a commonly prescribed first-line option for smoking cessation due to its unique mechanism of action as a norepinephrine-dopamine reuptake inhibitor. This medication not only helps reduce withdrawal symptoms and cravings associated with quitting smoking but also has the added benefit of reducing the likelihood of weight gain, which is a concern for many individuals trying to stop smoking. Its utility in smoking cessation is well-supported by clinical studies, making it a preferred choice for healthcare providers.

In contrast, other medications such as sertraline and citalopram, which are selective serotonin reuptake inhibitors (SSRIs), primarily target depressive disorders and have not shown the same effectiveness in aiding smoking cessation. Mirtazapine, an atypical antidepressant, is used primarily for treating depression and anxiety; it doesn't have the same evidence base for smoking cessation as bupropion. Thus, bupropion remains the standout medication when considering first-line options for individuals aiming to quit smoking.