Which symptom might indicate hypokalemia as a side effect of beta-agonist therapy?

Muscle weakness is a recognized symptom of hypokalemia, which can occur as a side effect of beta-agonist therapy. Beta-agonists, such as albuterol, are commonly used in the treatment of conditions like asthma and chronic obstructive pulmonary disease (COPD). These medications can lead to hypokalemia through several mechanisms, including increased potassium influx into cells and enhanced renal potassium excretion.

When potassium levels drop, muscle cells may not function optimally, leading to general muscle weakness and fatigue. This symptom is particularly relevant because it directly reflects the physiological effects of low potassium levels affecting muscle contraction and nerve function.

In contrast, other symptoms included in the list do not directly relate to hypokalemia. Chest pain can be associated with many cardiovascular issues, including anxiety or angina, and shortness of breath is commonly linked to respiratory problems rather than electrolyte imbalances. Similarly, headaches can be caused by numerous factors, such as dehydration or tension, rather than specifically indicating low potassium levels. Thus, muscle weakness stands out as the most directly related symptom to hypokalemia resulting from beta-agonist therapy.